loss of consciousness in general anesthesia
Conditions
Interventions
Group 1:Intravenous injection of propofol (0.15mg/kg)
Group 2:Intravenous injection of propofol (0.20mg/kg)
Group 3:Intravenous injection of propofol (0.25mg/kg)
Group 4:Intravenous injection of propofol (0.30mg/kg)
Group 5:Intravenous injection of propofol (0.35mg/kg)
Group 6:Intravenous injection of propofol (0.40mg/kg)
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: ASA Level I-III; Selective surgery; Age 18-85 years old; Patient or authorized person signs informed consent form
Exclusion criteria
Exclusion criteria: Bradycardia (HR2mg/dl); Poor control of hypertension (SBP>160mmHg after taking antihypertensive drugs), or poor control of blood sugar in diabetes patients (HbA1c>9%) Patients who plan to undergo regional block before anesthesia induction; Pregnant women; History of drug addiction; Glaucoma; Peripheral arterial disease; Severe mental illness; History of allergic reactions to experimental drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50;ED95; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dose-response relationship between respiratory depression, BIS, and hemodynamic endpoints;Postoperative recovery quality of continuous infusion of cyclophenol; | — |
Countries
China
Contacts
Public ContactChao Liang
Zhongshan Hospital, Fudan University
Outcome results
None listed