acute respiratory distress syndrome
Conditions
Interventions
Experimental group:Silverestana0.2mg/kg/h Venous pumping
control group:Normal saline
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Age =18 years old (2) It meets the diagnostic criteria of ARDS Berlin. (3) ARDS caused by pulmonary factors (4) Oxygenation index =100mmHg (5) Diagnosis of ARDS < 72 hours
Exclusion criteria
Exclusion criteria: (1) Pregnant women, breastfeeding women (2) ARDS caused by extrapulmonary factors (3) Brain death (4) End-stage tumors or other diseases (5) Treatment was abandoned after admission to ICU, and mechanical ventilation and cardiopulmonary resuscitation were not agreed (6) Severe chronic lung disease (combined with chronic respiratory failure) (7) Combined with congestive heart failure (8) Respiratory and cardiac arrest (9) Severe hemodynamic instability (10) Refuse to participate in this study or have participated in other researchers (11) Hospice (12) Extra-pulmonary SOFA=6 points (13) Ulinastatin, thymphatin and Xuebijing were used within 72 hours before enrollment (14) Glucocorticoid use =1mg/kg/ day within 7 days before enrollment (15) Known allergy to cilvelestat sodium or excipients or to other substances covered by the examination (16) Participants who had used an IL-6 antagonist (such as tocilizumab) or a JAK inhibitor in the previous week were enrolled
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index improvement rate on day 8; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement rate of inflammation index on day 8;On day 8, the proportion of ARDS grading improvement;Mechanical ventilation withdrawal time;28-day all-cause fatality rate;In-hospital mortality;Incidence of hospital feeling;Safety index;Pharmacoeconomic indicators (ICU hospitalization costs, drug costs); | — |
Countries
China
Contacts
Public ContactGuo Chenxia
Peking University Third Hospital
Outcome results
None listed