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Comprehensive evaluation of prognostic risk score prediction model construction and its clinical application based on a real-world artificial liver for liver failure cohort

Construction of a prognostic risk score prediction model for artificial liver treatment of liver failure cohort and its clinical application research plan

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300078667
Enrollment
Unknown
Registered
2023-12-14
Start date
2024-01-01
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver disease

Interventions

ALSS group:NA

Sponsors

The Second Hospital of Nanjing
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with liver failure diagnosed with reference to the Asia-Pacific Liver Failure and the Chinese Medical Association Liver Failure Diagnostic and Treatment Guidelines, norms, etc.; over 18 years of age, less than 70 years of age; progressive deepening of jaundice (TBIL = 171 µmol/L or daily rise of = 17.1 µmol/L); hospitalized, with indications for artificial liver therapy, and proposed to carry out artificial liver therapy patients.

Exclusion criteria

Exclusion criteria: Maternity; end-stage liver disease or liver failure combined with non-hepatic secondary failure of extrahepatic organs; uncontrolled acute bleeding; established irreversible infections; intestinal dysfunction GIF scores greater than 2 Patients not scheduled for DPMAS therapy alone or in combination with plasma exchange with irregularities in their primary drug therapy. Participation in this study was deemed unsuitable in the judgment of the investigator.

Design outcomes

Primary

MeasureTime frame
AIC/BIC;AUC;Model calibration evaluation;Evaluation of model clinical applicability;

Countries

China

Contacts

Public ContactYishan Zheng

The Second Hospital of Nanjing

doctor0219@163.com+86 137 7077 7171

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026