rectal cancer
Conditions
Interventions
Photodynamic group,:Photodynamic therapy
Photodynamic + compound matrine group:Photodynamic therapy combined with compound matrine
Sponsors
Yichun people's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) patients with low advanced rectal cancer confirmed by colonoscopy, pathology and imaging; (2) no opportunity for surgery (for rectal stenosis and intestinal obstruction caused by huge tumors, which cannot be controlled by conventional treatment) or surgical conditions; (3) The patient strongly refused surgery. (4) unable to tolerate or refuse chemoradiotherapy; (5) No contraindications to photodynamic therapy: no allergy to photosensitizer, no serious coagulation disorders and other diseases that could affect the implementation of photodynamic therapy. (6) the expected survival time is more than 3 months; (7) The patients or their family members signed the informed consent of photodynamic therapy and compound matrine injection.
Exclusion criteria
Exclusion criteria: (1) patients allergic to photosensitizers; (2) patients with severe or uncontrolled cardiovascular and pulmonary diseases, or unstable vital signs due to various reasons; (3) patients with obvious coagulation dysfunction; (4) original hematoporphyria or other diseases aggravated by light, such as systemic lupus erythematosus, dermatomyositis, etc.; (5) patients with eye diseases who need to receive an ophthalmic light examination within the past one month; (6) Use with caution in pregnant and lactating women who plan to undergo surgery within 30 days; (7) no serious systemic diseases, such as uncontrolled active infection; (8) The patient was in a cachectic state, and the expected survival time was less than 3 months. (9) previous radiotherapy or chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| remission rate;quality of life; | — |
Countries
China
Contacts
Public ContactHuizhen Fan
Yichun people's Hospital
Outcome results
None listed