perioperative neurocognitive disorders
Conditions
Interventions
D group:Dexmedetomidine 0.5µg/kg/hmaintained anesthesia
S group:Dexmedetomidine was replaced with normal saline, and the rest method was the same as group D
Sponsors
The second hospital of hebei medical university
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: elderly patients undergoing ERCP surgery; ASA Grade II~ III; Age > 65 years old; Able to complete all preoperative cognitive function tests independently.
Exclusion criteria
Exclusion criteria: Exclusion criteria: (1) the patient's written informed consent was not obtained; (2) Patients who received a second elective operation during the same hospital stay; (3) combined with mental system diseases; (4) A history of severe liver and kidney dysfunction, severe hypertension, diabetes and coronary heart disease; (5) Alcoholic and drug abusers were assessed as preoperative cognitive disabled by Mini Mental Status Examination (MMSE); (6) Patients or family members request withdrawal from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE score; | — |
Secondary
| Measure | Time frame |
|---|---|
| systolic pressure;heart rate;mean arterial pressure;Recovery time for spontaneous breathing;postoperative adverse events; | — |
Countries
China
Contacts
Public ContactSun Zhangnan
The second hospital of hebei medical university
Outcome results
None listed