Breast cancer
Conditions
Interventions
Intervention group:Analgesic intervention
Control group:None
Sponsors
Second Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1: Breast cancer patients with musculoskeletal pain receiving a 3-week taxane regimen 2: Age: 18-75 years old 3: ECOG score: 0-2 4: Normal hematology, heart, liver and kidney function 5: At least 3 cycles of paclitaxel 6: Expected survival for more than three months 7: No obvious infection and serious diseases of other organs 8: Patients gave informed consent and were able to fill out the questionnaires themselves or with assistance.
Exclusion criteria
Exclusion criteria: 1: Have obvious clinical patients with heart, liver and kidney damage 2: Concomitant use of drugs that attempt to prevent/treat neuropathy 3: Concomitant use of neurotoxic therapies 4: Patients with poor compliance 5: Patients with symptomatic brain or bone metastases with pain 6: Patients allergic to paclitaxel or its excipients 7: The celecoxib, tramadol allergies 8: Allergic to sulfonamides 9: Taking aspirin or other non-steroidal anti-inflammatory drugs (nsaids) after induced asthma, urticaria, or allergic reaction of the patients 10: Patients with active GI ulcers/bleeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of severe TAPS; | — |
Secondary
| Measure | Time frame |
|---|---|
| FACT-B, FACT-B TOI ;The incidence of severe TAPS in each cycle, Incidence, severity, and duration of TAPS per cycle;Quality of Life Scale Score, BPI Life Intervention Score, ENS and FACT-Nxt Score;Adverse reaction; | — |
Countries
China
Contacts
Public ContactChen Xinxin
Second Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed