Carotid stenosis/Internal carotid stenosis
Conditions
Interventions
sugammadex group:sugammadex (2mg/kg) will be given at TOFc=2 after surgery
neostigmine + atropine group:neostigmine (0.02mg/kg) + Atropine (0.01mg/kg) will be given at TOFc=2 after surgery
Sponsors
Xuanwu Hospital of CCMU
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Age 18 years or older, diagnosed with carotid artery stenosis; Patients undergoing endotracheal intubation under general anesthesia; Patients who received the non-depolarizing muscle relaxant rocuronium bromide during surgery; The American Society of Anesthesiologists (ASA) has a body condition rating of I to III.
Exclusion criteria
Exclusion criteria: Patients with severe abnormalities of heart, lung, liver or kidney function; Patients with neuromuscular dysfunction due to various reasons; Patients with neuromuscular block contraindications and hypersensitivity to neostigmine or sugen sodium; Intraoperative massive bleeding and malignant arrhythmia caused by various reasons; Changes in surgical procedures (including patients using a bypass tube during surgery, patients requiring carotid stent placement after CEA, and patients undergoing hybridization (CEA+ angiography); After the operation, the recovery was delayed, and the duration of extubation was =30 min. Patients who are participating in other studies or who declined to participate in this study; Patients undergoing other procedures at the same time; Patients who lost follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference of cerebral blood flow fluctuation between neostigmine group and sugenose sodium group during recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| extubation time;The fluctuation of arterial blood pressure during extubation between groups;Heart rate fluctuation during extubation between groups;Differences in incidence of diencephalic hyperperfusion between groups;Differences in incidence of hypoxemia between groups;Differences in the incidence of hypercapnia between groups;Differences in the incidence of postoperative pulmonary complications between groups;Differences in the incidence of postoperative adverse cardiac events between groups;Differences in the incidence of postoperative neurological complications between groups;Eye opening time;Duration of stay in anesthesia recovery room;Postoperative hospital stay;Dosage of vasoactive drugs such as deoxyadrenalin, urapidil, nicardipine, esmolol during extubation; | — |
Countries
China
Contacts
Public ContactZhao Lei
Xuanwu Hospital of CCMU
Outcome results
None listed