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PROFOUND Study: Development and Validation of a Multi-cancer Early Detection Model Based on Peripheral Blood Multi-omic Analysis and Machine Learning: a Multicenter, Prospective, Observational, Case-control Study

PROFOUND Study: Development and Validation of a Multi-cancer Early Detection Model Based on Peripheral Blood Multi-omic Analysis and Machine Learning: a Multicenter, Prospective, Observational, Case-control Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300078560
Enrollment
Unknown
Registered
2023-12-12
Start date
2023-12-28
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

cancer patients group:None
control group:None

Sponsors

Peking University People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.It is clinically and/or pathologically diagnosed as any of 16 cancers such as lung cancer, colorectal cancer, liver cancer and other non-target cancers; 2.40 years old = age < 75 years old; 3.Prior to screening, he had not received any systemic or local anti-tumor therapy, including but not limited to surgical resection, chemoradiotherapy, endocrine therapy, targeted therapy, immunotherapy, cell therapy, interventional therapy, etc; 4.Sign informed consent and agree to follow the sampling, evaluation, and interview requirements for this study.

Exclusion criteria

Exclusion criteria: 1.Pregnant and lactating women; 2.People with a history of other cancers; 3.History of severe acute infectious diseases (such as severe and critical COVID-19 infection, sepsis, etc.) or fever exceeding 38.5 °C within 14 days prior to screening; 4.Use of the following drugs in the 14 days prior to screening: intravenous/oral glucocorticoids; 5.Intravenous/oral use of azacitidine, decitabine, procainamine, hydrazine, arsenic trioxide; 6.Have received an organ transplant, bone marrow transplant, stem cell transplant or blood transfusion within 30 days before screening; 7.Other situations deemed unsuitable for participation in this study by the investigator.

Design outcomes

Primary

MeasureTime frame
sensitivity;specificity;Tissue traceability accuracy;

Countries

China

Contacts

Public ContactJun Wang

Peking University People's Hospital

wangjun@pkuph.edu.cn+86 137 0110 5360

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026