ulcerative colitis
Conditions
Interventions
Test group:fecal microbiota transplantation capsule
Sponsors
Army Medical Center(Daping Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Male or female, adults aged 18-75. 2.Patients who meet the diagnostic criteria for UC in the Consensus Opinion on the Diagnosis and Treatment of Inflammatory Bowel Disease (2018 • Beijing). 3.Poor response to conventional drugs (including 5-aminosalicylic acid, corticosteroids, immunosuppressants), the modified Mayo score ranges from 6 to 12, and the modified Truelove and Witts disease severity scores are moderate to severe. 4.Patients who voluntarily agree to participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with other serious diseases, such as respiratory failure, heart failure, severe immunodeficiency, indications for surgery, or a history of colon surgery. 2.Patients with a history of combined diseases that affect the gut microbiota, such as metabolic syndrome and autoimmune diseases. 3.Women in the preparation, pregnancy, or lactation period. 4.Use antibiotics or probiotics within 1 week before enrollment. 5.Patients with contraindications to gastrointestinal endoscopy or a history of severe allergies. 6.Patients undergoing other clinical studies within 4 week before enrollment. 7.Patients with poor compliance and difficulty in completing follow-up. 8.Other reasons that researchers think are not suitable for enrollment or patients withdrawing from the trial due to their own reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Simple Clinical Colitis Activity Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified MAYO Score;biomarkers;Mucosal healing rate;Change in gut microbiota; | — |
Countries
China
Contacts
Public ContactYanling Wei
Army Medical Center(Daping Hospital)
Outcome results
None listed