Anxiety and depression
Conditions
Interventions
Test group:After induction for 5 minutes, continue to pump 0.2-0.3 mg/kg of Esketamine for 20 minutes
Control group:Continuously pump physiological saline 0.2-0.3mg/kg for 20 minutes after induction for 5 minutes
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Age 18 or above; (2) ASA grading 1-2, without other serious systemic diseases; (3) Patients who have undergone more than 2 trauma repair surgeries; (4) Patients with preoperative scores of = 22 on the Montgomery Depression Rating Scale and = 10 on the PHQ-9 Scale; (5) Voluntarily sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with other mental illnesses; (2) Patients with contraindications to ketamine use or a history of allergy to other opioid drugs; (3) Patients with a history of cerebral infarction; (4) Patients who have used hormones within the past month; (5) Patients who have been drinking excessively or taking sedatives and analgesics for a long time; (6) Patients with diabetes or rheumatic immune diseases; (7) Refusing to participate in the trial patients; (8) Patients with preoperative hemoglobin below 90g/L; (9) A clear diagnosis of depression in patients before surgical trauma; (10) Patients expected to enter the ICU after surgery; (11) Patients with MMSE score<18;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Three days after surgery, the Montgomery Eisberg depression score decreased by 50% compared to baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| After treatment, the Montgomery Eisberg depression score was = 10;PHQ-9 ;Athens insomnia scale;Hospital anxiety and depression scale; | — |
Countries
China
Contacts
Public ContactQiang Fu
Chinese PLA General Hospital
Outcome results
None listed