Median Effective Dose of Esketamine Co-administered with Propofol for Cervical Conization or Hysteroscopic Surgery with Patients Spontaneous Breath: an up-and-down sequential allocation study

Median Effective Dose of Esketamine Co-administered with Propofol for Laryngeal Mask Airway Insertion without Neuromascular Blocking Agents: an up-and-down sequential allocation study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300078529

Enrollment

Unknown

Registered

2023-12-12

Start date

2023-12-12

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical conization or hysteroscopy

Interventions

Test group:co-administer with esketamine and propofol, patients breathe spontaneously

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients scheduled to cervical conization or hysteroscopic surgery and the grade of American Society of Anesthesiologists is I to III.

Exclusion criteria

Exclusion criteria: 1) uncontrolled high blood pressure (> 180/110 mmHg); 2) allergy to esketamine of propofol; 3)difficult airway; 4) upper respiratory tract infection; 5) regurgitation history; 6) BMI > 30 kg/m2

Design outcomes

Primary

Measure	Time frame
success rate of completing the surgery ;heart rate at each time point;respiratory rate at each time point;	—

Secondary

Measure	Time frame
time from drug administration to loss consciousness ;blood pressure at each time point;	—

Countries

China

Contacts

Public ContactPing Zhao

Shengjing Hospital of China Medical University

taobd@icloud.com+86 189 4025 5594

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026