nasopharyngeal carcinoma
Conditions
Interventions
Experimental group:diammonium glycyrrhizinate
Control Group:Oral Care Education
Sponsors
Jiangxi Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Initial diagnosis of NPC patients 2) clinical stage I-IVa stage (UICC AJCC 8th edition) 3) receiving radical IMRT with or without chemotherapy 4) ECOG PS 0-2 5) Age 18-70 years 6) male or non-pregnant, lactating female 7) without hypernatremia and hypokalemia 8) hematologic examination: WBC > 4 × 109 L, neutrophil > 2 × 109 L, hemoglobin > 90 g/L, platelets >100 × 109 L 9) liver and kidney function: Alt, Ast GT; 60 ml/min) 10) signs an informed consent form
Exclusion criteria
Exclusion criteria: 1) allergic to diammonium glycyrrhizinate or soybean phospholipids 2) history of other malignancies (except basal-cell carcinoma squamous cell carcinoma of the skin and carcinoma in situ of the cervix) 3) history of radiotherapy (non-melanoma of the skin outside the target area of planned irradiation 4) serious concomitant disease that may pose a risk to the trial or affect compliance, such as unstable heart disease requiring treatment, kidney disease, chronic hepatitis, poorly controlled diabetes mellitus and psychosis 5)patients refused to be enrolled
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| radiotherapy induced oral mucositis ;Days of use of hormones, antibiotics, and antifungal agents;Extension of radiation therapy days;Anemia after radiotherapy;The incidence of hypoalbuminemia;3-year progression free survival rate (PFS);3-year overall survival rate (OS); | — |
Countries
China
Contacts
Public ContactTang Yiqiang
Jiangxi Cancer Hospital
Outcome results
None listed