elderly patients in laparoscopic surgery
Conditions
Interventions
OFA:Before induction: ultrasound-guided bilateral TAP block was performed, and 20 ml of 0.375% ropivacaine was injected separately.
Induction: propofol 1.5-2 mg/kg, esketamine 0.2-0.5 mg/kg and cis-at
TGA :Before induction: ultrasound-guided bilateral TAP block was performed and 20 ml of 0.375% ropivacaine was injected separately.
Induction: propofol 1.5-2mg/kg, sufentanil 0.3-0.5µg/kg and cis-atra
Sponsors
The Third People's Hospital of Bengbu
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Elderly patients admitted to the participating centers, age range: 60 to 80; 2) undergoing laparoscopic surgery; 3) signed informed consent; 4) ASA grade?-?.
Exclusion criteria
Exclusion criteria: 1) patients allergic to narcotic drugs or intraoperative adjuvant drugs; 2) patients with severe arrhythmia; 3) patients with poor control of hypertension; 4) coronary heart disease, angina pectoris and myocardial infarction; 5) patients with severe cardiopulmonary abnormalities; patients with 6) intraocular pressure or high intracranial pressure; 7) hyperthyroidism; 8) long-term use of anticoagulant drugs or abnormal coagulation function; 9) long-term history of analgesic drugs; 10) patients with mental illness or unable to communicate normally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15;Levels of IL-1, IL-6, T-lymphocyte subsets, NK cells, and B-lymphocytes before intubation and after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative and postoperative visual analog scores (VAS) of pain in dynamic and static conditions were assessed in both groups at 2h, 6h, 12h, 24h, and 48h;Blood pressure and heart rate at preoperative (T0), preintubation (T1), postintubation (T2), skin incision (T3), 30min (T4), and end of surgery (T5);Intraoperative: dosage of vasoactive drugs;Postoperative: time to extubation, cognitive impairment, nausea and vomiting, cumulative amount of remedial analgesia and sufentanil in 48h; time to puncture site infection or hemorrhage, time to deflation, and time to hospitalization; | — |
Countries
China
Contacts
Public ContactZhang Zhiqiang
The Third People's Hospital of Bengbu
Outcome results
None listed