postpartum depression
Conditions
Interventions
Control group:During induction, 5ml normal saline, 2mg·kg-1 propofol, 4ng·ml-1 remifentanil and 0.6mg·kg-1 rocurium bromide were administered intravenously
Esketamine group:The patients were induced to receive esketamine 0.25mg·kg-1 diluted to 5ml, propofol 2mg·kg-1, remifentanil 4ng·ml-1 effect chamber target concentration controlled infusion (TCI), roc
Sponsors
The Fourth Hospital of Shijiazhuang
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) ASA grade II-III; (2) Before starting activities related to the test, voluntarily sign informed consent, fully understand the purpose and significance of the test, and voluntarily comply with the test procedure; (3) Subjects who intend to undergo elective cesarean section under general anesthesia; (4) 18 years old =40 years old; (5) Expected duration of surgery =2h; (6) Prenatal body mass index (BMI) <35kg/m2 after pregnancy.cy.
Exclusion criteria
Exclusion criteria: (1) Patients with a history of stroke, cognitive dysfunction and epilepsy; (2) Patients with a history of myocardial infarction, angina pectoris, or a history of degree II or above atrioventricular block and other severe arrhythmias within 6 months before screening; (3) pregnancy combined with other diseases (malignant tumor, pregnancy-induced hypertension, thyroid dysfunction, etc.); (4) Peripheral blood oxygen saturation (SpO2) was less than 92% in the non-oxygenated state; (5) Continuous use of sedative, analgesic and hypnotic drugs for 3 months before randomization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EPDS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;MAP; | — |
Countries
China
Contacts
Public ContactZhang Jin
The Fourth Hospital of Shijiazhuang
Outcome results
None listed