Critical illness
Conditions
Interventions
Intervention Group:In addition to standard nutrition therapy, all participants in this group will receive an infusion of pectin (citrus pectin) along with enteral nutrition at a rate of 90 pectin per
Control Group:Patients in this group received only standard nutritional therapy. Patients should start gastric feeding within 48 hours of enrollment, gradually increase the feeding speed, and reach 70
Sponsors
Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Admitted to ICU 48 hours; 4. Do not expect to feed orally for more than 3 days and plan to receive gastric feeding; 5. No operation plan within a week; 6. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who had started enteral nutrition before admission to ICU; 2. Patients who have had a nasointestinal tube placed and are scheduled to receive enteral feeding; 3. Patients with contraindications to enteral nutrition; 4. Patients receiving palliative care or expected to die within 48 hours; 5. Pregnant or nursing patients; 6. The doctor believes that this patient needs a high-calorie (or low-calorie) nutritional regimen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the ratio of EN energy intake to the prescribed target energy on Day 5 after randomization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to initiation of enteral nutrition;Average daily energy intake within the first 7 days after enrollment;Average daily protein intake within the first 7 days after enrollment;Daily Bristol stool score within the first 7 days after enrollment;Daily Feeding Intolerance Score (FIS) within the first 7 days after enrollment;Daily Gastrointestinal Dysfunction Score (GIDS) within the first 7 days after enrollment;Proportion of patients who transition to postpyloric feeding within the first 7 days after enrollment;Proportion receiving arenteral nutrition within the first 7 days;Caloric adequacy on Days 3, 5, and 7, defined as achieving at least 80% of the estimated energy target;Protein adequacy on Days 3, 5, and 7, defined as achieving at least 70% of a target of 1.3 g/kg/day;Daily serum albumin during the first 7 days after enrollment;Daily serum prealbumin during the first 7 days after enrollment;Daily C-reactive protein (CRP) during the first 7 days after enrollment;Daily blood urea nitrogen during the first 7 days after enrollment;Duration of ICU stay;Duration of hospital stay;Duration of mechanical ventilation;28-day mortality;ICU-free to 28 days;Hospital-free days to 28 days;Ventilation-free days to 28 days;Incidence of new-onset organ failure within 7 days after enrollment;New receipt of organ support within the first 7 days;Number of organ support–free days during this period;Daily SOFA scores recorded over the first 7 days; | — |
Countries
China
Contacts
Public ContactBaiqiang Li
Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
Outcome results
None listed