gout
Conditions
Interventions
Refractory gout group, adolescent onset gout group, premenopausal female gout group:NA
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: criteria for joining the group: (1) Age: 18-80 years old patients with hyperuricemia / gout. (2) definite diagnosis of hyperuricemia [serum uric acid = 2 times > 420 umol / L (about 7mg/dL)]. (3) whether the patient agrees to participate in this trial and has signed an informed consent form. (4) gout was clearly diagnosed according to the 2015 classification criteria of the American Rheumatic Society / European Alliance against Rheumatic Gout. (5) patients with chronic gouty arthritis who have not been treated before or have never received treatment before, if they have been treated with regular enough uric acid lowering drugs (non-bustar 40-80mg/d or allopurinol 0.3-0.6g/d), the uric acid continues to be substandard, the attack frequency continues to increase, gouty stone can not be softened or reduced or the symptoms are still difficult to control, the number or volume of gouty stone continues to increase.
Exclusion criteria
Exclusion criteria: exclusion criteria: (1) malignant tumor / hematological tumor is under treatment. (II) lactating / lactating women or women planning to become pregnant. (3) chronic renal failure (CKD5 stage, i.e. eGFR < 15ml/min/1.73 failure).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RNA sequencing and gene expression analysis;Metabolomics data analysis and its correlation with DEGS;Gene sequencing to explore uric acid and gout related SNP loci; | — |
Countries
China
Contacts
Public ContactXuejun Zeng
Peking Union Medical College Hospital
Outcome results
None listed