ADHD
Conditions
Interventions
Gold Standard:The ADHD participants were divided into two sub-groups: medication responders, who have a reduction rate of over 25% of the total score of the ADHD rating scale after 12 weeks of pharmac
Index test:Use Independent component analysis (ICA) for the data reduction of the imaging genetic measures, e.g., polygenic risk score, cortical thickness/surface area/BOLD signal of the frontal lobe,
Sponsors
Shenzhen Children's Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 9 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for the ADHD group are as follows: (1) A clinical diagnosis of ADHD based on DSM-5 and semi-structured interview by K-SADS-PL; (2) Aged 6-9 years; (3) Normal full-scale intelligence quotient (IQ) measured by the Wechsler Intelligence Scale for Chinese Children-IV (WISC-IV) (=80); (4) Normal Vision or normal corrected vision; (5) Right-hand dominant; (6) No visible brain abnormalities on the MRI images, e.g., arachnoid cyst; (7) No past or current history of contraindication for MRI, e.g., claustrophobia; As for the control group, the inclusion and exclusion criteria are the same as the ADHD group except for the diagnosis of ADHD.
Exclusion criteria
Exclusion criteria: The exclusion criteria for the ADHD and the Control group include: (1) A history of head injury with loss of consciousness; (2) Any drug or substance misuse; (3) A present or past diagnosis of other psychiatric disorder (comorbiding CD and ODD is allowed in the ADHD group); (4) History of using prescribed medications for ADHD or other psychiatric disorders;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specificity; | — |
Countries
China
Contacts
Public ContactZhaomin Wu
Shenzhen Children's Hospital
Outcome results
None listed