Psychological pressure
Conditions
Interventions
Placebo/control group:placebo
Treatment group:probiotics (Lactobacillus paracasei K56)
Sponsors
China Agricultural University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Undergraduate or master's or doctoral students expected to graduate in June-July 2024; 2. Aged 18-35 years; 3. Chronic stress caused by graduation pressure (scientific research, thesis or job seeking), and moderate stress is screened by Stress Perception Scale (PSS).
Exclusion criteria
Exclusion criteria: 1. The main source of stress is not graduation (scientific research, thesis or job seeking), but because of emotion, illness, etc. 2. Suffering serious gastrointestinal diseases (such as gastric ulcer, Crohn's disease, ulcerative colitis, etc.), diabetes, liver disease, kidney disease, heart disease and other chronic diseases; 3. Currently taking medication for constipation, diarrhea, or psychological disorders (depression, anxiety, insomnia, etc.); 4. Have used antibiotics in the past 4 weeks; 5. Currently taking probiotic supplements and unwilling to stop taking them at least 2 weeks before the start of the study; 6. Excessive smoking, alcohol or drug abuse; 7. Women who are pregnant or breastfeeding or plan to become pregnant in the next 6 months; 8. Allergic to milk ingredients; 9. Have serious mental illness, such as major depression, bipolar disorder, schizophrenia, etc; 10. Taking medications that may affect the primary or secondary outcome of the study; 11. Taking a drug known to affect the metabolism of the investigational drug; 12. The presence of irregular schedules that may impede the adoption of intervention strategies; 13. Participating in other clinical trials within the last 30 days or currently; 14. Cannot follow research protocols.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perceived Stress Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression Anxiety Stress Scale;Gastrointestinal Symptom Rating Scale;Pittsburgh Sleep Quality Index;Insomnia Severity Index;Patient Health Questionnaire;Fatigue Severity Scale;Inflammatory cytokines;Cortisol;Zonulin;Gut microbiota;Gut microbial metabolites;International Physical Activity Questionnaire;Bristol Stool Scale; | — |
Countries
China
Contacts
Public ContactJingjing He
China Agricultural University
Outcome results
None listed