Colorectal cancer
Conditions
Interventions
Experimental group:Esketamine was injected intravenously 30 minutes before the end of the procedure(0.2mg/kg,20ml)
Control group:20ml of normal saline was injected intravenously within 30 minutes before the end of the operation
Sponsors
Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Sign the informed consent form 2. Patients who plan to undergo laparoscopic colorectal cancer surgery under general anesthesia; 3. Aged between 18 and 75 years old; 4. ASAI~ Level III; 5. The operation is expected to last between 1 and 6 hours.
Exclusion criteria
Exclusion criteria: 1. Patients with known gastrointestinal motility disorders; 2. Abuse of narcotic sedatives and analgesics; 3. History of abdominal surgery; 4. Allergic to esketamine or other narcotic drugs; 5. Severe liver and kidney dysfunction; 6. Preoperative gastrointestinal bleeding (bleeding volume >800ml); 7. Emergency reoperation patients; 8. People with mental illness; 9. History of airway difficulty or prolonged extubation; 10. Other situations deemed unsuitable for inclusion by researchers (specific reasons should be indicated).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of patient's first aerofluxus; | — |
Secondary
| Measure | Time frame |
|---|---|
| I-FEED score;Time of first defecation;Time of first oral feeding;Incidence of delirium;Postoperative pain score;Sleep quality score;Postoperative nausea and vomiting score;Hospitalization costs and length of stay; | — |
Countries
China
Contacts
Public ContactXiang Li
Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed