Clinical study of stellate ganglion block combined with tropisetron in preventing postoperative nausea and vomiting in gynecological laparoscopic patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300078428

Enrollment

Unknown

Registered

2023-12-07

Start date

2021-11-29

Completion date

Unknown

Last updated

2023-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gynecological patients who require laparoscopic surgery

Interventions

Group S:0.5% lidocaine 5mL planetary ganglion block after general anesthesia induction+1mL saline intravenous injection after surgery

Group ST:After induction of general anesthesia, 0.5% lidocaine 5mL planetary ganglion block+intravenous injection of 5mg (1mL) of bitropisetron

Group T:Intravenous injection of 5mg (1mL) of Sabidosetron

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ? Under the age of 18-65 years old, female in gender, with an ASA rating of I-III; ? At that time, the surgery was laparoscopic oophorectomy or laparoscopic hysterectomy; ? Not receiving radiotherapy or chemotherapy before surgery; ? Stable vital signs and clear language; ? No autoimmune diseases; ? The patient and their family members have informed consent to participate in this experiment and signed an informed consent form.

Exclusion criteria

Exclusion criteria: ? Apply antihistamine or other anti emetic drugs to stop vomiting before surgery; ? SGB contraindications or failure to block; ? Individuals who are allergic to 5-HT3 receptor antagonists; ? Unable to communicate with doctors normally; ? Having severe cardiovascular and cerebrovascular diseases; ? Abnormal coagulation function.

Design outcomes

Primary

Measure	Time frame
Postoperative nausea and vomiting incidence;Severity of postoperative nausea and vomiting;	—

Secondary

Measure	Time frame
Postoperative Analgesics Usage;Postoperative use of antiemetic drugs;Postoperative Pain Visual Analog Scale (VAS);Intraoperative systolic blood pressure of patients;Intraoperative diastolic blood pressure of patients;Mean intraoperative arterial pressure of the patient;Patient surgical center rate;Postoperative recovery time;First postoperative exhaust time;Postoperative headache incidence;The incidence of postoperative sleep disorders;Postoperative skin itching incidence;Incidence of postoperative respiratory depression;	—

Measure

Time frame

Postoperative Analgesics Usage;Postoperative use of antiemetic drugs;Postoperative Pain Visual Analog Scale (VAS);Intraoperative systolic blood pressure of patients;Intraoperative diastolic blood pressure of patients;Mean intraoperative arterial pressure of the patient;Patient surgical center rate;Postoperative recovery time;First postoperative exhaust time;Postoperative headache incidence;The incidence of postoperative sleep disorders;Postoperative skin itching incidence;Incidence of postoperative respiratory depression;

—

Countries

China

Contacts

Public ContactMa Hong

The First Hospital of China Medical University

mahong5466@126.com+86 138 4036 6406

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026