The effect of preoperative medication with atropine, pentylenethyclidine, and glucuronium bromide on postoperative recovery in elderly patients: a randomized controlled double-blind clinical trial

The effects of preoperative medication with glucuronium bromide, pentylethyl ether, and atropine on postoperative recovery (including delirium) in elderly patients undergoing endoscopic esophageal mucosal dissection

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300078413

Enrollment

Unknown

Registered

2023-12-07

Start date

2023-12-08

Completion date

Unknown

Last updated

2023-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative recovery

Interventions

G group:Intramuscular injection of 0.005mg/Kg of glucuronium bromide 30 minutes before surgery

A group:Intramuscular injection of atropine 0.01mg/kg 30 minutes before surgery

P group:Intramuscular injection of 0.01mg/kg pentylenethyclidine 30 minutes before surgery

NS group:Intramuscular injection of 2ml of physiological saline 30 minutes before surgery

Eligibility

Sex/Gender

All

Age

61 Years to 75 Years

Inclusion criteria

Inclusion criteria: 576 elderly patients aged 60-75 years old with a BMI of 18-28 Kg/m2 who underwent endoscopic mucosal dissection (ESD) at six tertiary hospitals in Sichuan Province from December 2023 to July 2024 were included.

Exclusion criteria

Exclusion criteria: Exclusion criteria: Patients with bronchial asthma, glaucoma, prostate enlargement, pyloric obstruction, history of choline drug allergy, liver and kidney dysfunction, cardiac dysfunction, recent clinical trials with other drugs, history of mental disorders and family mental illness, hearing impairment and inability to communicate normally, preoperative cognitive dysfunction or accompanied by delirium, moderate to severe brain injury within 3 months before surgery, Patients or family members refuse to sign informed consent for the trial.

Design outcomes

Primary

Measure	Time frame
Confusion Assessment Method (CAM) ;	—

Secondary

Measure	Time frame
MMSE;RASS;QOR-15;Salivary secretion;	—

Countries

China

Contacts

Public ContactFangjun Wang

Affiliated Hospital of North Sichuan Medical College

wfjlxy006@nsmc.edu.cn+86 134 5825 3172

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 22, 2026