myelofibrosis
Conditions
Interventions
Gold Standard:bone marrow biopsy
Index test:FAPI-PET/CT
Sponsors
The First Aiffiliated hosptical of xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age =18 years old; (2) Cohort 1: Patients with suspected or confirmed myelofibrosis; Cohort 2: Patients with primary/secondary myelofibrosis who were not treated with ruxolitinib . (3) The expected survival time is greater than 3 months (4) Voluntarily sign informed consent. (5) Willing and able to follow the research protocol; (6) The subject must be able to lie on the scanning bed for 20 minutes;
Exclusion criteria
Exclusion criteria: (1) Known allergic history to 68Ga FAPI or its excipients; (2) Patients who can not tolerate intravenous drug administration (such as needle fainting and blood fainting history); (3) Those who are not suitable for or unable to complete imaging tests such as PET due to special reasons, including claustrophobia and radiophobia; (4) pregnant and lactating women; (5) Workers who are exposed to radiation for a long period of time; (6) serious diseases of the heart, kidney, lung, blood vessel, nervous system, mental system, immune deficiency diseases and hepatitis/cirrhosis; (7) Participating in other interventional clinical trials within 1 month before screening; (8) Patients undergoing chemotherapy, immunotherapy or molecular targeted therapy due to other cancers; (9) There are other circumstances that the researcher thinks are not suitable for participating in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;Specificity;Positive prediction rate;Negative prediction rate; | — |
Countries
China
Contacts
Public ContactBing Xu
The First Aiffiliated hosptical of xiamen University
Outcome results
None listed