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Study on the Neuroimaging Mechanisms of Cognitive Impairment in Patients with Severe Lower Limb Ischemia Based on Multimodality

Study on the Neuroimaging Mechanisms of Cognitive Impairment in Patients with Severe Lower Limb Ischemia Based on Multimodality

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300078401
Enrollment
Unknown
Registered
2023-12-07
Start date
2023-12-08
Completion date
Unknown
Last updated
2025-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral Artery Disease

Interventions

Group of patients with Critical Limb Ischemia (CLI) :There was no intervention in this group. This group was the patient group, without external treatment, only the patient group completed the head MR
Healthy control Group::None

Sponsors

Shanxi Bethune Hospital and Shanxi Academy of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients Group: Patients with Critical Limb Ischemia (CLI) are recruited from the outpatient and inpatient departments of Shanxi Bethune Hospital. Inclusion criteria: (1) Meet the diagnostic criteria for CLI; (2) Aged 50-80 years, gender not specified, right-handed; (3) Have not taken any psychoactive drugs in the month prior to enrollment; (4) Willingly participate in this study and sign an informed consent form. 2. Healthy control Group: A healthy control group is recruited concurrently. Inclusion criteria: (1) Select individuals whose gender, age, and educational level match those of the experimental group; (2) Aged 50-80 years, gender not specified, right-handed; (3) Have never received any psychoactive drugs or undergone brain physical therapy.

Exclusion criteria

Exclusion criteria: 1. Patients Group: (1) Pain not caused by CLI in the past month; (2) Suffering from other mental illnesses or organic brain diseases; (3) History of receiving physical therapies like electroconvulsive therapy or transcranial magnetic stimulation; (4) History of drug abuse or addiction; (5) Contraindications for MRI, such as claustrophobia or internal metal implants. 2. Healthy control Group: (1) Past diagnosis of mental disorders; (2) Family history of mental disorders or organic brain diseases; (3) History of pain in the past month; (4) Contraindications for MRI, such as claustrophobia or internal metal implants.

Design outcomes

Primary

MeasureTime frame
MRI data ;

Secondary

MeasureTime frame
MoCA scale;NRS scale;

Countries

China

Contacts

Public ContactYu Tian

Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences; Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University

tianyu21@mails.tsinghua.edu.cn+86 159 0346 6955

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026