stroke
Conditions
Interventions
high frequency rTMS:high frequency rTMS on iIPL
sham rTMS:sham rTMS on cM1
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) first-ever stroke (2) diagnosed by computed tomography or MRI as subcortical ischemic or hemorrhagic stroke (3) clear consciousness and stable vital signs (4) age between 18 and 80 years, regardless of gender (5) between 2 weeks to 6 months following stroke onset (6) unilateral upper limb and hand hemiplegia (Modified Brunnstrom classification as grade I-IV) (7) right handed according to the Edinburgh Handedness Inventory (8) voluntarily sign an informed consent form and are willing to participate in this study Healthy subjects (1) 18-80 years old, regardless of gender; (2) Right handedness; (3) Voluntary signing of informed consent form;
Exclusion criteria
Exclusion criteria: (1) severe speech, attention, hearing, visual, sensory, intellectual, mental, or cognitive impairments (MMSE 2) of the affected upper extremity or significant pain on the affected side (Ten-point Visual Analog Scale > 4) (3) osteoarthritis or other serious neurological disorders (4) from other cities and unable to be followed up (5) alcohol or drug addiction (6) malignant tumors (7) severe cardiovascular diseases such as heart failure, severe respiratory diseases such as lung infections, severe liver diseases such as ALT>2 times the upper limit of normal, kidney diseases such as creatinine>the upper limit of normal, and other unstable clinical symptoms (8) epilepsy (9) contraindications to rTMS such as metal implant, magnetic sheet or cardiac pacemaker (10) still enrolled in any rehabilitation or drug studies (11) pregnancy Healthy subjects (1) Have any history of serious physical or brain diseases in the past; (2) Simultaneously participating in other relevant clinical researchers; (3) Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FM-UL;ARAT;WMFT;BI;MEP; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS;Brunnstrom;MMT;fMRI assessment; | — |
Countries
China
Contacts
Public ContactLimin Sun
Huashan Hospital, Fudan University
Outcome results
None listed