Disorders of consciousness after craniocerebral injury
Conditions
Interventions
Observational studies-Intervention group:NA
Observational studies-Control group:NA
Intervention study-intervention group:The 100f transcranial magnetic stimulator and "8" wire from Nanjing Weisi were used for iTBS.
The iTBS treatment was performed with a 100f transcranial magnetic s
the iTBS stimulation intensity was 75% of the resting motor threshold
the basic frequency of iTBS mode was 5Hz. The basic frequency of iTBS mode was 5 Hz, and 1 short burst of stimulation was given every 200 ms, in which 3 individual pulses at 50 Hz were buried in each
iTBS was administered to both sides of the cerebellum separately with a 5-minute interval. The iTBS treatment was carried out separately on both sides of the cerebellum with an interval of 5 minutes
iTBS treatment was carried out once a day, 5 times a week, for 4 weeks.
Intervention study-control group:The only difference between the intervention and control iTBS treatment groups is the orientation of the "8" coil: In the intervention group, the "8" coil was aligned
Sponsors
The First Affiliated Hospital of Gannan Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: ? Age = 18 years, regardless of gender; ?stable condition within 1 month of onset; ?Primary illness was craniocerebral trauma, stroke or ischemic-hypoxic encephalopathy; ? presence of DOC, meeting the international diagnostic criteria of UWS/VS and MCS; ? Immediate family members of the patient agreed to participate in this study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria: ? No CNS disease other than the primary disease; ?Current use of central excitatory or sedative drugs; ? having recent seizures or being on anti-epileptic drugs; ?have other serious medical conditions with a life expectancy of less than 3 months; ? have a contraindication to MRI or are unable to cooperate in completing an MRI; ? Contraindication to iTBS therapy or inability to cooperate with completion of iTBS therapy; ? Patients who do not comply with follow-up or have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rs-fMRI examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| CRS-R Score;Electroencephalogram examination and analysis; | — |
Countries
China
Contacts
Public ContactLuo Yun
The First Affiliated Hospital of Gannan Medical University
Outcome results
None listed