Spinal disease
Conditions
Interventions
Short term cognitive decline group (patients will develop cognitive decline in the short term):None
Short term normal cognitive function group (patients with no postoperative cognitive change):None
PNCD group (patients develop into PNCD in the long-term):None
Non-PNCD group (patients will not develop into PNCD in the long-term):None
Testing-set PNCD group (patients develop into PNCD in the testing set):None
Testing-set non-PNCD group ( patients will not develop into PNCD in the testing set):None
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 64; 2. ASA classification I -II; 3.18kg /^2<=BMI<=30kg/^2; 4. Diagnosis of spinal diseases, including disc herniation, spinal stenosis, and space occupying lesions in the spinal canal, etc.; 5. Right-handed.
Exclusion criteria
Exclusion criteria: 1. A history of delayed recovery after anesthesia or cognitive impairment; 2. Non-right-handed; 3. Have a history of contraindications to anesthesia and drug allergy; 4. Cervical tumor has caused paralysis; 5. Atypical cervical tumor; 6. Heart, liver, lung and renal insufficiency; 7. With MRI scanning contraindications; 8. Maternal or lactating women; 9. Refuse to participate in this researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Connectivity (FC) and Topological structures of the Default Brain Network; | — |
Secondary
| Measure | Time frame |
|---|---|
| Confusion Assessment Method (CAM) scale score;Montreal Cognitive Assessment (MoCA) scale score;Mini-mental State Examination (MMSE) scale score;auditory verbal learning test (AVLT);Daily Living Ability scale (ADL) ;Clinical Dementia Scales (CDR);Clock Drawing Task (CDT);Shape Trails Test B (STT-B) and Trail Making T;Hamilton Depression Scale (HAMD);Hamilton Anxiety Scale (HAMA);Hachinski Ischemia Scale;Fluency Test;Inflammatory cytokines;Cerebrospinal fluid nerve function index (GFAPtau/p-tauS-100ßAßNFL);The connectivity and topological structure of other brain networks (central executive network and salience network);Potential confounding factors (Age, weight, height, educational level, operation and anesthesia time, preoperative cognition and quality of life assessment scale scores);Recovery time (extubation and return to ICU);Duration of hospitalization;Postoperative outcome of patients (Glasgow score, steward score, muscle strength score, postoperative adverse incidence); | — |
Countries
China
Contacts
Public ContactLiu Yang
Xuanwu Hospital, Capital Medical University
Outcome results
None listed