chronic endometritis
Conditions
Interventions
Experimental group and control group:Oral doxycycline
Experimental group and control group:Oral minocycline
Sponsors
Lan Zhou University Second Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: ? Premenopausal women who still need to have children; ?CD138 immunohistochemical staining showed more than 1 plasma cell per 10HPF. ? No endometrial hyperplasia or malignant or structural pathological features of the uterus; (4) Consent to perform a second endometrial biopsy approximately 4 to 6 weeks after the first endometrial biopsy; ? Obtain informed consent from patients and their families, and sign informed consent.
Exclusion criteria
Exclusion criteria: ? Had received steroid hormone therapy and other antibiotic therapy within 1 month before recruitment; ? Allergy or suspected allergy to the test drug; (3) positive pregnancy tests (tetracycline antibiotics can pass through the placenta, can be found in fetal tissue to produce toxic effects on fetal development, so pregnant women prohibited); (4) lactating women (minocycline hydrochloride can be secreted in human milk, so lactating women prohibited);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immunohistochemical examination of endometrial tissue shows a negative conversion rate of CD138+cells; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunohistochemical examination of endometrial tissue shows a negative conversion rate of CD56/57+cells;TBNK lymphocytes;Th1 and Th2 cytokines;live birth rate; | — |
Countries
China
Contacts
Public ContactFang Wang
Lan Zhou University Second Hospital
Outcome results
None listed