Infertility
Conditions
Interventions
pretreatment group:GnRH antagonist administration from day 2 of the menstrual cycle for 3 days
control group:No GnRH antagonist administration from day 2 of the menstrual cycle for 3 days
Sponsors
Northwest women and children’s Hospital
Eligibility
Sex/Gender
Female
Age
35 Years to 42 Years
Inclusion criteria
Inclusion criteria: (1) IVF patients with antagonist protocol (2) Age: 35-42 years old (3) Uneven follicles during initiation: Maximum follicle diameter on day D2 of menstruation - minimum follicle diameter = 3-4mm
Exclusion criteria
Exclusion criteria: (1) Oocyte donation cycles (2) Body mass index>=28 kg/m2 (3) Uterine anatomical abnormalities, endometrial or myometrial lesions: Uterine malformations (unicorn uterus, bicornuate uterus, bicornuate uterus, mediastinal uterus); Adenomyosis of the uterus; Patients with uterine fibroids (fibroids larger than 3cm or closely related to the endometrium); Submucosal uterine fibroids; Uterine adhesions; Untreated endometrial polyps. (4) There is unilateral or bilateral hydrosalpinx that has not been surgically removed or ligated. (5) Endocrine disorders, such as hyperprolactinemia and thyroid diseases with abnormal TSH (6) Recurrent spontaneous abortion (= 2 clinical abortions) 3 IVF attempts, or multiple implantation failures (no clinical pregnancy after surgery) = 3 transplants, with less than one high-quality embryo transferred each time (7) According to the revised American Society of Reproductive Medicine classification (1985), stage III-IV endometriosis. (8) Frozen oocytes, pre implantation genetic testing, or chromosomal karyotype abnormalities in spouses (9) The use of combination therapy or any other situation where the researcher believes that interfering with the trial or cannot ensure the safety and effectiveness of the data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cumulative ongoing clinical pregnancy rate (>12 weeks); | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of retrieved oocytes;Oval corona cumulus sinus follicle index;cumulative active yield; | — |
Countries
China
Contacts
Public ContactShi Wenhao
Northwest Women’s and Children’s Hospital
Outcome results
None listed