Pleural infection
Conditions
Interventions
B:Urokinase was injected into the chest
C:Medical thoracoscopy combined with intrathoracic injection of urokinase
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Clinical evidence of infection (as assessed by the competent physician, evidence of infection includes elevated fever, inflammatory markers, such as elevated CRP and white blood cells); Pleural effusion is present at the same time, and the pleural effusion is characterized (with any of these criteria) as gross purulent, positive for bacterial culture, positive for gram staining, or PH < 7.2 (blood gas analysis).
Exclusion criteria
Exclusion criteria: ?. Age < 18 years old; (2) Before receiving fibrinolytic drugs (urokinase, streptokinase, DNase or tPA) treatment; 3. allergic to urokinase; (4) coincidental stroke; ?. Massive bleeding or severe trauma; 6. Unable to tolerate thoracoscopic surgery due to hemodynamic instability or severe hypoxemia; 7. Surgical operation within 5 days, or previously performed ipsilateral thoracic surgery; 8. pregnancy or lactation; ?. Expected survival of less than 3 months, due to diseases other than pleural disease; ? Continuous thoracic drainage was performed before enrollment (without extubation), and no replacement of thoracic drainage tube was required after clinical evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change rate of pleural shadow;Incidence of adverse reactions (complications); | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospitalization;Total hospitalization expenses; | — |
Countries
China
Contacts
Public ContactLi Weimin
West China Hospital of Sichuan University
Outcome results
None listed