Postpartum depression
Conditions
Interventions
Observation group:Esme ketamine 0.25mg/kg +0.9% normal saline diluted into 20ml micro pump injection for 40 minutes
Control group:0.9% normal saline 20ml micro pump injection for 40 minutes
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
Female
Age
19 Years to 43 Years
Inclusion criteria
Inclusion criteria: It meets the diagnostic criteria of post depression in the diagnostic and Statistical Manual of mental disorders (5th Edition) (DSM-V), and the Edinburgh Postpartum Depression Scale (EPDS) score = 13 points; First diagnosed cases with complete medical records; Primary school education or above; No pregnancy complications or complications; No endocrine urinary system or nervous system diseases; Sign informed consent
Exclusion criteria
Exclusion criteria: Previous family history of psychosis or mental history; People with intellectual or cognitive impairment; Depression caused by other organic diseases or post-traumatic stress; Poor compliance, unable to cooperate with researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum serotonin (5-HT);Dopamine;Norepinephrine;Brain-derived neurotrophic factor;Orphanin; | — |
Secondary
| Measure | Time frame |
|---|---|
| EPDS;Hamilton depression scale, HAMD;Hamilton Anxiety Scale; | — |
Countries
China
Contacts
Public ContactJiang Qinyu
Xuzhou Central Hospital
Outcome results
None listed