Alzheimer
Conditions
Interventions
Drug therapy group:The dose of Donepezil was increased to 10mg/d for 12 weeks. If the patient has insomnia, change to morning medication
Combined treatment group A:High frequency rTMS true stimulus (stimulus parameters are as follows: the stimulus frequency is 20Hz
The stimulation duration was 2s and the interval was 28s. Each target stimulated 15 sequences with 600 pulses, a total of 60 sequences with 2400 pulses, a total treatment time of 30 minutes) +5mg/d Do
Combined treatment group B:High frequency rTMS sham stimulus +5mg/d Donepezil
Sponsors
Shandong First Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 89 Years
Inclusion criteria
Inclusion criteria: ? Meet the Diagnostic and Statistical Manual of Mental Disorders Revised IV and the Working Group standards of the National Academy of Neurology, Speech and Communication Disorders, and Stroke-Alzheimer's Disease and Related Disorders; ? All patients were Han and right-handed; ? Education level of 8 years or above; (4) Complete all clinical and cognitive behavioral scales required by the experiment; (5) Move freely without the help of others; ? No history of alcohol consumption or drug dependence; ? No epilepsy and family history; No MRI contraindications, such as claustrophobia and metal implants.
Exclusion criteria
Exclusion criteria: ? Have a history of severe trauma or mental illness; ? Patients with severe ischemic lesions; ? Patients with depression and/or anxiety; ? patients with arteriosclerosis or leukoporosis; ? Overweight, Body Mass Index (BMI) = 28.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| structural magnetic resonance imaging,sMRI;diffusion tensor imaging,DTI; | — |
Primary
| Measure | Time frame |
|---|---|
| Cognitive behavioral assessment; | — |
Countries
China
Contacts
Public ContactDong Cui
Shandong First Medical University
Outcome results
None listed