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Multi-center clinical study of Huanglong Mixture in the treatment of children with cough variant asthma based on multi-omics analysis and screening of diagnosis and treatment markers

Multi-center clinical study of Huanglong Mixture in the treatment of children with cough variant asthma based on multi-omics analysis and screening of diagnosis and treatment markers

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300078336
Enrollment
Unknown
Registered
2023-12-05
Start date
2023-12-20
Completion date
Unknown
Last updated
2023-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cough variant asthma

Interventions

Healthy control group:None
Western medicine group:Montelukast
Chinese medicines group:Huanglong mixture

Sponsors

Nanjing Hospital of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 18 Years

Inclusion criteria

Inclusion criteria: (1) 3-18 years old; (2) In line with the diagnostic standards of traditional Chinese and western medicine, the syndrome differentiation of traditional Chinese medicine was wind heat trapping phlegm; (3) Stop bronchodilators and/or hormones 2 weeks before starting treatment; (4) Informed consent of the guardian of the child.

Exclusion criteria

Exclusion criteria: (1) Patients who do not meet the above diagnostic criteria of traditional Chinese and Western medicine, or whose age range is not 3-18 years old; (2) those allergic to two groups of drugs; (3) Patients with other typical primary diseases, such as liver disease, kidney disease, blood disease, cardiovascular disease and metabolic disease, which may affect the results of this clinical trial; (4) Patients who did not use the drug according to the standard, could not judge the efficacy or had incomplete data affecting the efficacy evaluation; (5) Participants in clinical trials of other drugs.

Design outcomes

Primary

MeasureTime frame
FEV1/FVC;EO%;IgE;

Secondary

MeasureTime frame
PEF;Blood routine;MEF25%;FeNO;NEUT%;

Countries

China

Contacts

Public ContactLong Hongyan

Nanjing Hospital of Chinese Medicine

hongyan3128@163.com+86 189 5175 5050

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026