To explore the efficacy and mechanism of ' Tiaoshen Yizhi Acupuncture ' combined with rTMS in the treatment of mild cognitive impairment based on fNIRS technology.

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300078335

Enrollment

Unknown

Registered

2023-12-05

Start date

2024-01-01

Completion date

Unknown

Last updated

2023-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mild cognitive impairment

Interventions

acupuncture groups:'Tiaoshen Yizhi Acupuncture ' + conventional drug treatment

union groups:" Tiaoshen Yizhi Acupuncture " combined with rTMS + conventional treatment group

conventional treatment group:conventional drug treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ( 1 ) Meet the diagnostic criteria of MCI ; ( 2 ) Neuropsychological assessment confirmed the existence of cognitive impairment, that is, the definite damage of = 1 cognitive domain or the critical damage of = 2 cognitive domains, which did not meet the diagnostic criteria of dementia. MMSE 17 points, primary school ( education years = 6 years ) > 19 points, middle school or above ( education years > 6 years ) > 24 points ; ( 3 ) over 18 years old ; ( 4 ) Basic daily life self-care, and Barthel index > 60 points ; ( 5 ) Patients or family members signed informed consent, willing to accept and cooperate with the research program.

Exclusion criteria

Exclusion criteria: ( 1 ) unable to cooperate with the researcher due to mental illness, severe cognitive or emotional disorders ; ( 2 ) serious heart, respiratory, digestive, urinary system and other life-threatening diseases ; ( 3 ) Patients without long-term living or care ; ( 4 ) pregnant, planned or lactating women ; ( 5 ) Acute cerebrovascular accident occurred within 2 weeks ; ( 6 ) Cognitive dysfunction caused by intracranial infection ; ( 7 ) Patients with cardiac pacemaker.

Design outcomes

Primary

Measure	Time frame
mmse score;MOCA score;App protein;Inflammatory factors ( IL-6, CRP, PCT, TNF-a );fNIRS neural network activity detection;	—

Countries

China

Contacts

Public ContactBingjie He

Guangzhou Panyu Health Management Center ( Guangzhou Panyu Rehabilitation Hospital )

hbj20080508@163.com+8613392125580

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026