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Influence and mechanism of follicular fluid exosomes on in vitro fertilization (IVF) in women with autoimmune diseases

Influence and mechanism of follicular fluid exosomes on in vitro fertilization (IVF) in women with autoimmune diseases

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300078333
Enrollment
Unknown
Registered
2023-12-05
Start date
2024-01-01
Completion date
Unknown
Last updated
2023-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

autoimmune diseases

Interventions

autoimmune group:NA

Sponsors

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Age: Female patients aged 18 to 50 years 2. Must meet at least any autoimmune disease diagnosis or have clear autoimmune abnormality test results, including patients with systemic lupus erythematosus, systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, antiphospholipid syndrome and thyroid autoimmune diseases 3. Voluntary donation and excess waste gametes, embryos, follicular fluid, and culture fluid 4. Voluntarily sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Identify reproductive failure caused by other non-autoimmune disease causes 2. Be over 50 years old 3. There is no remaining waste gamete embryo follicular fluid and culture medium available 4. Ovarian cancer, endometrial cancer, cervical cancer, etc. and other systemic tumor lesions; 5. Patients with severe mental illness; 6. Chromosomal abnormalities; 7. Patients who refuse to participate in this study and who are not followed up

Design outcomes

Primary

MeasureTime frame
maturation rate;Fertilization rate;Cleavage rate;Available embryo rate;Available number of embryos;

Countries

China

Contacts

Public ContactJin Lei

Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

leijintjh@163.com+86 27 8366 2534

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026