Allergic disease
Conditions
Interventions
Healthy control group:No special intervention
Blank control group with high risk of allergy:No special intervention
High-risk probiotic intervention group:1*10^9 colony-forming units of M-1V probiotics were administered daily
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: Newborns at hiah risk of allera. family history of atopic disease. defned as one or more family members (mother. father. or older siblinas) withallergic eczema allergic rhinitis. or asthma.Healthy controls were defined as those without family history of atopic diseases
Exclusion criteria
Exclusion criteria: 1,Severe henatic dusfunction.renal dysfunction. cardiovascula disease. respiratory dysfunction.endocrine disorder, or metabolic dysfunctioduring pregnancy. She had a history of antibiotic use within 1 month before delivery 2, Premature or post-term birth,severe pulmonary dysplasia, conenital heart disease. diaestive tract malformation and other birth defectshistony of birth asphyxia, neonatal use of antibiotics. 3,Habitual intake of probiotic supplements during pregnancy or plan to give other probiotic or prebiotic supplements to intants 4, Mothers who have participated in other clinical trials within 8 weeks or are participating in other drug clinical trials 5,According to the researchers' judgment, other diseases or conditions that may reduce or complicate enrollment, such as unstable living environment and inconvenient transportation, are likely to cause loss of follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atopic dermatitis SCORAD score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Allergy-related symptom Score (CoMisS);Fecal calprotectin;flora analysis;Metabolite analysis; | — |
Countries
China
Contacts
Public ContactYi YU
Ruijin Hospital, Shanghai Jiao Tong UniversitySchool of Medicine
Outcome results
None listed