Dry eye disease
Conditions
Interventions
Healthy group:None
Sponsors
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria of dry eye group: 1)Age between 18-65 years old, male or female. 2)Patients meet the criteria of the Expert Consensus on Dry Eye in China: Definition and Classification (2020) in a single eye or in both eyes on the following ophthalmic test results: Patients who have dryness, foreign body sensation, burning, visual fatigue, ocular redness and blurred vision with ocular surface disease index (OSDI)=13. Simultaneously, fluorescein breakup time (FBUT) =5s, or noninvasive breakup time (NIBUT) <10s, or Schirmer-I test (SIT) (without anesthesia) value = 5 mm/5 min. Or patients with dry eye syndrome score OSDI=13. And FBUT between 5s and 10s, or a SIT value between 5 mm/5 min and 10mm/5 min, and corneal fuorescein staining (CFS) scale=5 points. 3)Intraocular pressure ranges from 10 to 21mmHg. 4)Patients voluntarily to receive FSN treatment and sign the informed consent form. 2. Inclusion Criteria of healthy group: 1) Not diagnosed with dry eye disease. 2) Intraocular pressure ranges from 10 to 21mmHg. 3) Age between 18-65 years old, male or female.
Exclusion criteria
Exclusion criteria: 1)Eye structure changes such as corneal ulcer, atresia of lacrimal gland opening, complete atrophy of accessory lacrimal gland, eyelid relaxation, etc. Diseases with unclear interstitial diopter, such as cataract; Fundus lesions such as macular edema, diabetic retinopathy, etc. Or with other eye diseases such as glaucoma, optic nerve disease, allergic conjunctivitis, etc. 2)Patients who have undergone ophthalmic surgery within the last six months. 3)Take medications which lead to dry eye such as isotretinoin and antidepressants. 4) Use of other medications for dry eye, wear contact lenses or corneal contact lens in the past week. 5) Patients with Sjogren's syndrome, facial palsy, thyroid eye disease, vitamin A deficiency, goiter, coagulation disorders, local skin infection, severe diseases and such as heart, cerebrovascular, liver and kidney and hematopoietic system. 6) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optical coherence tomography angiography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain pressure threshold;Cervical range of motion;Hamilton anxiety scale;proteomics; | — |
Countries
China
Contacts
Public ContactYong Sun
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Outcome results
None listed