Irritable Bowel Syndrome with Predominant Diarrhea
Conditions
Interventions
sensitive acupoints group:Pain thresholds were measured at 17 acupoints. Six acupoints (four bilateral acupoints and two single acupoints) with the highest sensitization degree were selected for acupu
sham acupuncture group:In this group, ten non-acupoints are chosen. The shallow needling method was used to penetrate the skin of the patient, and the needle tip was only penetrated 2-3mm under the sk
Sponsors
Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years (either sex); 2. Meets the diagnostic criteria of diarrheal-predominant irritable bowel syndrome (IBS-D); 3. Type 6 or 7 of the Bristol Stool Form Scale appeared for at least 4 days and type 1 or 2 appeared for less than 4 days in the last 2 weeks. The average score of daily abdominal pain was >= 3 in the last week; 4. No treatment of acupuncture in the last 6 months.
Exclusion criteria
Exclusion criteria: 1. Other sub -type IBS: IBS-C/ IBS-M/ IBS-U; 2. Participants with inflammatory bowel disease, microscopic colitis, celiac disease, Crohn's disease, and other organic bowel diseases (aged >= 50 years or have the following alarm signs that will be required to provide colonoscopy report within nearly 2 years: unexplained weight loss (weight loss > 10% within 3 months), hematochezia caused by non-hemorrhoids or anal fissure, nocturnal diarrhea, family history of colorectal cancer); 3. Use of antidepressant or IBS medication within 2 weeks before treatment, including traditional Chinese medicine (TCM) or proprietary Chinese medicine, antidiarrheal, antispasmodic, intestinal antibiotics, probiotics, and so on; 4. Diabetes mellitus ,abnormal thyroid function, severe acute or chronic organic diseases and kidney or liver diseases; 5. History of previous abdominal surgery (appendectomy, hemorrhoidectomy, or polypectomy greater than 3 months post-surgery is allowed); 6. Pregnancy or lactation; 7. History of alcohol and drug abuse; 8. Participate in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective response rate at week-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| Effective response rate at other time points;Effective response rate of 50% of the 6-weeks treatment period;IBS symptom severity scale, IBS-SSS;Symptoms of abdominal pain;Symptoms of bloating;Days of loose stools;Patient Health Questionnaire-9, PHQ-9;Quality of life questionnaire, IBS-QOL;IBS Adequate Relief, IBS-AR;The Extraintestinal Symptom Scale; | — |
Countries
China
Contacts
Public ContactCunzhi Liu
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine
Outcome results
None listed