Cesarean section postoperative pain
Conditions
Interventions
Group E:Immediately after severing the umbilical cord, S-ketamine hydrochloride injection 0.5mg/Kg was injected intravenously, and the administration time was limited to 60 ±10 seconds. At the end of
Group C:Immediately after the umbilical cord was severed, the same amount of normal saline was given to S-ketamine hydrochloride injection. After the operation, the patient-controlled intravenous anal
Sponsors
Fuling Hospital Affiliated to Chongqing University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) 20-45 years old; (2) Single pregnant women who underwent cesarean section under elective spinal anesthesia (3) ASA II-III (4) Voluntarily participated in the study and signed the informed consent
Exclusion criteria
Exclusion criteria: (1) parturients with contraindications for cesarean section, such as intrauterine stillbirth, fetal malformation, maternal intolerance to surgery, fetal distress, etc.; (2) parturients with contraindications to intraspinal anesthesia such as coagulation dysfunction and central system diseases; (3) parturients with contraindications to esketamine, such as hyperthyroidism, severe hypertension, preeclampsia, mental disorders, need to relax the uterus, such as umbilical cord prolapse and uterine rupture. (4) pregnant women who were addicted to alcohol and took opioids, hormones and anti-inflammatory and analgesic drugs for a long time; (5)parturients were allergic to the drugs used in the trial; and (6)those who could not cooperate with the study or refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| maxmum pain NRS score 24h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pressure pain threshold;Pressure pain tolerance;Serum C-reactive protein concentration;The time of patient-controlled analgesia for the first time after operation;Number of compressions of patient-controlled analgesia;Patient-controlled analgesia pump drug dosage;Dosage of Tramadol;Incidence of anxiety;Incidence of depression;Incidence of sleep disorders;Incidence of side effects of S-ketamine; | — |
Countries
China
Contacts
Public ContactJunhua Zhang
Fuling Hospital Affiliated to Chongqing University
Outcome results
None listed