perioperative neurocognitive disorders
Conditions
Interventions
remimazolam Group :Remazolam 6 to 12 mg/kg/h was used for anesthesia induction until loss of consciousness and remazolam 1.0 to 2.0 mg/kg/h for anesthesia maintenance
propofol group:Propofol (1-2 mg/kg) was used for anesthesia induction until loss of consciousness and propofol (4-12 mg/kg/h) was used for anesthesia maintenance.
Sponsors
The Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age= 60 2) Undergoing elective major surgery under general anesthesia under general anaesthesia with tracheal intubation(expected surgery time >2 h, expected length of postoperative stay >2 d); 3) ASA ?-?
Exclusion criteria
Exclusion criteria: 1) A history of psychiatric disorders (including preoperative delirium) or treatment with antipsychotics (chlorpromazine, haloperidol, clozapine, risperidone, olanzapine, quetiapine, etc., typical and atypical antipsychotics); 2) Preoperative Cognitive impairment determined by MMSE score; 3) Severe functional impairment of the auditory, visual, and speech systems; 4) Postoperative coma or seizures; 5) Severe hepatic and renal diseases (Child C or need for Preoperative Dialysis ); 6) Suspicion/evidence of narcotic sedative analgesic abuse or chronic use; 7) Difficult airway requiring awake intubation or adiagnosis of moderate to severe OSAS 8) Planned postoperative prolonged airway protection or need for mechanical ventilation 9) Allergic or contraindication to anaesthetics; 10) Recovering alcoholic; 11) Requirement for reoperation within 5 days after the first surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative delirium severity;Duration of postoperative delirium;Delayed neurocognitive recovery;Postoperative neurocognitive disorder; emergence delirium;activity of daily living;Quality of Life;Quality of recovery;Length of ICU stay;Length of hospital stay;Postoperative pain score; | — |
Countries
China
Contacts
Public ContactLi Hong
The Second Affiliated Hospital of Army Medical University
Outcome results
None listed