surgery
Conditions
Interventions
one:The binary endpoint evaluation and dose allocation principles based on biased coin design,adjusting the target effect site concentration (Ce) of remifentanil with ciprofol
two:The binary endpoint evaluation and dose allocation principles based on k-in-a-row design,adjusting the target effect site concentration (Ce) of remifentanil
three:The binary endpoint evaluation and dose allocation principles based on biased coin design,adjusting the target effect site concentration (Ce) of remifentanil with propofol
four:The binary endpoint evaluation and dose allocation principles based on k-in-a-row design,adjusting the target effect site concentration (Ce) of remifentanil with propofol
Sponsors
The Affiliated Heping Hospital of Changzhi Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Surgical operations; 2. Age 18-65 years old; 3. The American anesthesiologist association (ASA) is graded I-II; 4. Body mass index (body mass index, BMI) 18 ~ 28kg/m2.
Exclusion criteria
Exclusion criteria: 1.Allergies or contraindications to opioids, ciprofol,propofol and their components; 2. Use of other sedatives such as ciprofol or propofol or midazolam within 24 hours before surgery; 3.Patients with severe central nervous system, respiratory or circulatory system diseases; respiratory diseases,difficult airway,Liver dysfunction,renal dysfunction,mental disorders , long-term use of psychotropic drugs, and cognitive dysfunction,long-term use of psychotropic or sedative-hypnotic drugs,drug abuse and drinking; 4.Patients with Allen test positive,Hypertension, Hemodynamic instability (systolic blood pressure [SBP] 180 mmHg, diastolic blood pressure DBP > 110 mmHg, peripheral blood oxygen saturation [SpO2] < 90%); 5.Participation in other clinical studies within recent one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 90% effective concentration of remifentanil to inhibit tracheal intubation response for adult surgical patients(EC90); | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia depth index (AI);Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) score ;Systolic blood pressure, mean arterial pressure, and heart rate; | — |
Countries
China
Contacts
Public ContactJiaNing Guo
The Affiliated Heping Hospital of Changzhi Medical College
Outcome results
None listed