Postoperative cognitive dysfunction
Conditions
Interventions
control group:The end-tidal CO2 was maintained at 35-45 mmHg.
hypercapnia group:The end-tidal CO2 was maintained at 46-55 mmHg.
Sponsors
Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective thoracic surgery with one-lung ventilation 2.Age > 60 years old 3.mini-cog score = 2 points 4.ASA grade I-III
Exclusion criteria
Exclusion criteria: 1.Emergency surgery patients 2.History of central nervous system diseases : intracranial hypertension, craniocerebral surgery, cerebrovascular disease ( TIA, cerebral infarction, cerebral hemorrhage ), craniocerebral trauma. 3.Severe pulmonary dysfunction: preoperative pneumonia, atelectasis, pleural effusion, acute lung injury, ARDS 4.Severe liver and kidney dysfunction : Child-Pugh grade B, C, patients who need regular CRRT 5.Severe cardiovascular disease : acute coronary syndrome, LVEF < 45 %, second-degree, third-degree atrioventricular transmission Conduction block 6.SpO2 can not maintain more than 90 % in the resting state. 7.Preoperative cognitive dysfunction: Preoperative Mini-Cog scale score < 2 points. 6.Patients who need radial artery catheterization and central venous catheterization during operation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| regional cerebral oxygen saturation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary function;Hemodynamics;oxygenation index (PaO2/FiO2);intrapulmonary shunt fraction(Qs/Qt);ventilator parameters during one lung ventilation;postoperative cognitive function;postoperative delirium;Visual Analogue Scale; | — |
Countries
China
Contacts
Public ContactYao Weifeng
Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed