mild cognitive impairment
Conditions
Interventions
1:computerised cognitive training
3:computerized cognitive training combined with aerobic exercise
Sponsors
Shandong First Medical University&Shandong Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1.Elderly people living permanently in Tai'an City and aged =60 years old; 2.Subjects are able to understand instructions and communicate normally with researchers; 3.The study subjects met the scientific diagnostic criteria of the Chinese Expert Consensus 2021 on the Diagnosis and Treatment of Mild Cognitive Impairment of Alzheimer's Disease Origin: ? Cognitive impairment of the study subjects with chief complaint or confirmed by a knowledgeable person; ? Objective evidence of impairment in 1 or more cognitive domains in the study subjects (based on a score of < 26 points on Montreal Cognitive Functioning Assessment Scale (MoCA), and 1 point was added to the total score when the number of years of education was = 12 years);? the subjects do not meet the diagnostic criteria for dementia (CDR = 0.5); ? the subject's ability to perform activities of daily living is basically intact (based on a score of < 23 on the Activities of daily living (ADL) scale); 4.Study subjects had adequate education (primary school education and above) and had the ability to read, write and communicate effectively before the onset of the disease; 5.Subjects signed an informed consent form and volunteered to participate in the study.
Exclusion criteria
Exclusion criteria: 1.Study subjects with well-defined psychiatric and neurological disorders (e.g. schizophrenia, alcohol dependence, substance abuse, cerebral haemorrhage, massive cerebral infarction, transient ischaemic attack, epilepsy, Parkinson's disease, etc.); 2.Subjects with a history of craniocerebral trauma, cerebrovascular disease, coma or general anaesthesia in the last 6 months; 3.subjects with severe visual and hearing impairments; 4.Subjects who have participated in other research projects to improve cognitive function within the last 3 months; 5.Subjects who could not cooperate with the cognitive examination; 6.Subjects with severe heart disease, fractures, partial or complete paralysis, and other conditions affecting motor function; 7.Subjects who have exercised regularly in the last 3 months, i.e., exercise frequency >3 days per week and effective exercise (i.e., heart rate maintained at 100-140 beats/min) for >30 min per session.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global cognitive function;attention;memory;executive function;visuospatial function; | — |
Secondary
| Measure | Time frame |
|---|---|
| depression;apathetic;quality of life; | — |
Countries
China
Contacts
Public ContactWenyue Zhang
Shandong First Medical University&Shandong Academy of Medical Sciences
Outcome results
None listed