Depersonalization-derealization disorder
Conditions
Interventions
Test group:The electronic acupuncture instrument was used in this study to stimulate the vagus nerve through ear acupuncture. The auricular and earlobe areas of both ears were stimulated by the elect
current of =50mA (500O load impedance), using an intensity that was painless.
Control group:The electronic acupuncture instrument was used in this study to stimulate the vagus nerve through ear acupuncture. The auricular and earlobe areas of both ears were stimulated by the el
Sponsors
Beijing Anding Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with depersonalization disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), a score greater than 70 on the Cambridge Depersonalization Scale (CDS); (2) Age between 18 and 40 years old (inclusive ); (3) Comprehension of follow-up questionnaire survey; (4) No use of antipsychotic medication or the types and dosage of drugs were stable for 6 weeks, and did not receive acupuncture treatment ; (5) Able and willing to complete data collection through magnetic resonance imaging; and (6) Signed informed consent form and follow the research plan.
Exclusion criteria
Exclusion criteria: (1)Meet DSM-5 diagnostic criteria for other mental diseases except depersonalization disorder, such as schizophrenia, bipolar disorder, depression disorder, panic disorder, acute stress disorder, post-traumatic stress disorder or other separation disorders;(2) Severe or unstable physical disease; (3) Comorbid neurological disorders;(4) High risk of self-harm or suicide; (5) Pregnancy or lactation; (6) Contraindications to magnetic resonance imaging examination;(7) Need to take other psychotropic drugs besides the regulations during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in the CDS score during the six-week treatment period; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in HAMA and HAMD Scores at Each Visit During the 6-Week Treatment Period;Changes in Various Cognitive Function Indicators at Each Visit During the 6-Week Treatment Period;Changes in GAF, Q-LES-QSF, and WHOQOL-BREF Scores at Each Visit During the 6-Week Treatment Period;Changes in rs-fMRI Data Before and After the 6-Week Treatment Period;Changes in Safety Evaluation Indicators at Each Visit During the 6-Week; | — |
Countries
China
Contacts
Public ContactZhao Yan
Beijing Anding Hospital affiliated to Capital Medical University
Outcome results
None listed