Remifentanil–Induced Hyperalgesia
Conditions
Interventions
Group R:Remimazolam combined with remifentanil for anesthesia
maintenance
Group P :Propofol combined with remifentanil for anesthesia
maintenance
Group S :Sevoflurane combined with remifentanil for anesthesia
maintenance
Sponsors
Qilu Hospital, Cheeloo College of Medicine, Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1)diagnosed with lumbar disc herniation; (2)18–65 years old,; (3)BMI:18~30kg/m²; (4)classified as American Society of Anesthesiologists (ASA) physical status I or II; (5)scheduled for elective minimally invasive lumbar surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: (1)a history of lumbar surgery; (2)recent use of opioid drugs; (3)psychiatric disorders, neurological disease; (4)diabetes, renal or hepatic insufficiency,; (5)uncontrolled hypertension, or arrhythmia; (6)language impairment and inability to perform pain numrical rating scale ; (7)inability or refusal to use intravenous patient-controlled analgesia; (8)refusal to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mechanical pain threshold around the skin incision ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical pain threshold on the dominant inner forearm;NRS score at rest and after movement;Postoperative sufentanil consumption;Ramsay score;Awakening time and extubation time;Intraoperative hemodynamics at different time points;The use of intraoperative vasoactive drugs;Postoperative side effects;Postoperative comfort and satisfaction; | — |
Countries
China
Contacts
Public ContactShaozhong yang
Qilu Hospital, Cheeloo College of Medicine, Shandong University
Outcome results
None listed