Patients undergoing general anesthesia
Conditions
Interventions
Intervention group:10mg/kg Fospropofol Disodium
Control group:2mg/kg propofol
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) 65 years old = 18 years old, BMI=18-30kg/m2, ASA I-III level; (2) Perform elective surgery under simple general anesthesia; (3) Able to understand the research content and operations, and sign an informed consent form to be included in the study.
Exclusion criteria
Exclusion criteria: (1) Individuals who have experienced anesthesia accidents in the past; (2) Complicated neurological diseases: such as craniocerebral injury and stroke; (3) Patients with uncontrolled hypertension, severe hypotension, or heart disease prior to surgery; (4) Individuals with allergies or contraindications to experimental drugs or other anesthetic drugs; (5) Individuals who have participated in any drug clinical trial within one month prior to screening; (6) The researchers believe that subjects with any other unfavorable factors for participating in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area of mean arterial pressure (MAP) during the observation period at the hypotension threshold (65mmHg); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypotension incidence rate, hypotension incidence rate, hypertension incidence rate, maximum hypertension value, MAP area above the hypertension threshold (100mmHg) at observation period ;Bradycardia incidence, lowest heart rate, highest heart rate at observation period ;Systolic blood pressure, mean arterial pressure, maximum fluctuation value of heart rate (difference between maximum or minimum value and basic value) at observation period ; The lowest and highest BIS values areas with BIS less than 40, and areas with BIS greater than 60 during the observation period ;Time to start using inhaled anesthetics after intubation; Dosage of vasoactive drugs and proportion of patients using vasoactive drugs during observation period;Perioperative adverse reactions (injection pain, abnormal sensation, postoperative nausea and vomiting, etc.);The incidence of intraoperative awareness among patients (modified Brice assessment questionnaire, evaluation time point: before PACU and the first day after surgery);Satisfaction evaluation of anesthesiologists;Blood sample testing: ? Blood adrenaline concentration; ? Blood norepinephrine concentration; ? Blood cortisol concentration, etc; | — |
Countries
China
Contacts
Public ContactChan Chen
West China Hospital, Sichuan University
Outcome results
None listed