urothelial carcinoma
Conditions
Interventions
Gold Standard:pathological examination
Sponsors
Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Case group: 1. Male or female patient aged 18 or older; 2. Able to provide a 30 mL pre-treatment sample of morning or midstream urine; 3. Diagnosed as uroepithelial carcinoma of the bladder, ureter or renal pelvis by surgical pathology or biopsy pathology; 4. Patients with first diagnosis, without history of antitumor treatment, including antitumor drug therapy, surgical treatment, endocrine therapy, radiotherapy, etc., or no previous tumor history or postoperative and tumor recurrence. Control group: 1. Male or female patient aged 18 or older; 2. Patients able to provide a 30 mL pre-treatment sample of morning or mid-stream urine while receiving conventional treatment; 3. Diagnosed as urological malignancies by surgical pathology or biopsy pathology, other than urothelial carcinoma, including squamous cell carcinoma, adenocarcinoma of the bladder or other bladder-related cancers/prostate cancer/renal cancer; or clinically diagnosed with benign urological conditions, including urinary stones, urinary tract infections (other than urinary tract tuberculosis), prostatic hyperplasia. Healthy population: 1. Male or female patient aged 18 or older; 2. Able to provide a 30 mL morning or midstream urine sample within 1 month of physical examination; 3. Normal results of routine urinalysis/urinary ultrasound and no tumors in other organs.
Exclusion criteria
Exclusion criteria: 1. Patients with history of malignancy other than urological tumor; 2. Patients with history of antitumor treatment; 3. Patients unable to adhere to follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation;accuracy;Sensitivity;specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| DNA mutation;pathological examination;Urological imaging;urine cytology;Cystoscopy; | — |
Countries
China
Contacts
Public ContactFubo Wang
Guangxi Medical University
Outcome results
None listed