cataract
Conditions
Interventions
Control Group:Conventional cataract phacoemulsification was performed using normal perfusion BSS
Experimental group:Nicotinamide injection was added into the perfusion solution to perform conventional cataract phacoemulsification
Sponsors
Qingdao Eye Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosis of cataract and cataract phacoemulsification surgery, aged >= 60 years; 2. Cataract grade: according to the international standard (LOCS III) divided into grade 5 or above,
Exclusion criteria
Exclusion criteria: 1. Subjects with abnormal corneal endothelium or a history of corneal disease or surgery, such as Fuchs endothelial dystrophy, corneal endothelium less than 1500 /mm2, after penetrating corneal transplantation, etc. 2. Ocular trauma and surgical history; 3. Other ocular disease (inflammatory diseases such as uveitis, glaucoma, and severe retinopathy, etc) 4. Known allergy to experimental drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal endothelial cell loss rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| corneal thickness;visual acuity;intraocular pressure;Anterior chamber flare;Anterior chamber cell;Sensitivity parameters of corneal endothelial cell distortion (Xin value);anterior chamber depth;lens thickness;Cataract nuclear hardness; | — |
Countries
China
Contacts
Public ContactXiaoming Wu
Qingdao Eye Hospital of Shandong First Medical University
Outcome results
None listed