Acute respiratory distress syndrome
Conditions
Interventions
ARDS patients who can aspirate pulmonary edema fluid/ARDS patients who cannot aspirate pulmonary edema fluid/Patients with cardiogenic pulmonary edema who can aspirate pulmonary edema fluid:None
Healthy control group:None
Sponsors
Yantai Affiliated Hospital of Binzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) The patient is =18 years old; (2) Voluntary informed consent signed by the patient or guardian; (3) Fulfilment of the diagnostic criteria for ARDS as defined by Berlin (1. Acute or progressive dyspnoea presenting within 1 week of a clear trigger.2. Chest radiograph/chest CT showing infiltrative shadows in both lungs, which could not be fully explained by pleural effusion, lobar/total lung atelectasis, and nodular shadows.3. Respiratory failure that could not be fully explained by cardiac failure and fluid overload.4. Hypoxaemia PaO2 = (300 mmHg); (4) Patients with undiluted pulmonary oedema fluid that could be aspirated via suction tube or fibreoptic bronchoscope during hospitalisation, and patients with ARDS who were unable to aspirate pulmonary oedema fluid during the same period of time on a 1:1 match; (5) Patients with cardiogenic pulmonary oedema who can aspirate pulmonary oedema fluid.
Exclusion criteria
Exclusion criteria: (1) Combination of severe irreversible advanced diseases, such as various cancers and advanced cirrhosis; (2) Pregnant or lactating patients; (3) Other conditions that, in the opinion of the investigator, make it inappropriate for patients to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycocalyx metabolites;28 day mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic characteristics;blood biochemistry;Duration of mechanical ventilation;Length of hospitalisation;Length of ICU stay;90 day survival rate; | — |
Countries
CHINA
Contacts
Public ContactZhijiang Qi
Yantai Affiliated Hospital of Binzhou Medical University
Outcome results
None listed