Depressive Disorder
Conditions
Interventions
Experimental group 1:rTMS treatments
Pseudo-stimulus group 1:Pseudo-stimulation treatments
Experimental group 2:Antidepressants+rTMS stimulation
Pseudo-stimulus group 2:Antidepressants+rTMS pseudo stimulation
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Adolescents aged 12-18 years with depression; 2. Reach the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) Diagnostic criteria for depression; 3. Able to understand and complete the content of the scale; 4. Patients and guardians agree to participate in the study after fully understanding the study procedures and contents, and patients and guardians need to sign informed consent; 5. Normal control group: (1) No history of serious physical illness, head injury, or neurological disorders; (2) No previous history of mental illness; (3) Diagnosis of any mental illness that does not meet the DSM-V diagnostic criteria; (4) The patient and their family fully understand the research procedure and content before agreeing to participate in the study. Both the patient and their family members are required to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have a history of serious physical diseases, head trauma, and neurological diseases; 2. Previous history of alcohol dependence and psychoactive substance abuse; 3. There were ischemia, hypoxia, and severe birth injury at birth; 4. Organic brain problems were found in MRI examination; 5. There is a metal foreign body inside the skull; 6. With a pacemaker; 7. A history of epilepsy and a family history of epilepsy; 8. Meet the diagnosis of other major mental disorders in the DSM-V; 9. Participants with significant suicidal ideation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient Health Questionnaire-9 Score;Hamilton Depression Scale Score;Montgomery-Asberg deprssion sacle score; | — |
Secondary
| Measure | Time frame |
|---|---|
| General anxiety disorder scale score;Hamilton Anxiety Scale Score;Ottawa self-injury inventory score;Columbia Suicide Severity Rating Scale score;Young Mania Rating Scale Score;Positive and Negative Syndrome Score;Athens Insomnia Scale Score; | — |
Countries
China
Contacts
Public ContactShen Yanmei
The Second Xiangya Hospital of Central South University
Outcome results
None listed