Metastatic colorectal cancer
Conditions
Interventions
Case series:NO
Sponsors
Qingyuan People's Hospital, the Sixth Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) age =18 years old, patients sign informed consent; 2) Patients with metastatic colorectal cancer who are receiving or are planning to receive cetuximab therapy; 3) The presence of at least one RECIST measurable lesion (non-radiotherapy field) confirmed by CT or MRI;
Exclusion criteria
Exclusion criteria: 1) mCRC patients with KRAS, NRAS or BRAF gene mutations were detected by tissue molecular testing; 2) Previous history of organ transplantation, autologous/allogeneic stem cell transplantation; 3) A history of acute or subacute intestinal obstruction, or inflammatory bowel disease; 4) Active severe clinical infection (> Grade 2 NCI-CTCAE version 3.0), including active tuberculosis; 5) Known hypersensitivity or anaphylaxis to any component of the investigational treatment; 6) Pregnancy (confirmed by serum beta-chorionic gonadotropin test) or lactation(YNMT)·
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drug resistance ;Detection rate of KRAS mutation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection index Sensitivity; specificity; | — |
Countries
China
Contacts
Public ContactJinDuan Lin
Qingyuan People's Hospital, the Sixth Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed